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Football Predictions for Week 1 of NFL Against-the-Spread Games, along with Initial Odds to Explore

Week 1 of the NFL offers enticing ATS choices and early lines to exploit. Predictions and top picks against the spread are discussed, including the clash between DET and GB, and BAL vs BUF.

Week 1 NFL Picks Against the Spread and Early Line Opportunities to Exploit
Week 1 NFL Picks Against the Spread and Early Line Opportunities to Exploit

Football Predictions for Week 1 of NFL Against-the-Spread Games, along with Initial Odds to Explore

NFL Week 1 Preview: Key Matchups and Betting Trends

As the NFL season kicks off this week, several intriguing matchups and betting trends are worth highlighting.

The Minnesota Vikings, who boasted the second-best defense in the league in D-DVOA during the 2024 season, will face the Chicago Bears in a game that, while not explicitly mentioned in the search results, is likely to be one of the Week 1 contests. The line for this game opened with the Bears favored by 1.5 points, but has since swung in favour of the Vikings by the same number, due to early money pouring in on Minnesota.

Another highly anticipated game is the clash between the Buffalo Bills and Baltimore Ravens, a rematch of the AFC divisional round of the 2024 playoffs, which the Bills won 27-25. Buffalo's home record in Orchard Park dating back to 2023 is a formidable 18-2, and their defense has been bolstered significantly in the offseason by General Manager Brandon Beane. The Bills had a perfect 10-0 record at home in the 2024 season, including playoffs. The Ravens, on the other hand, were 6-4 in road games last year (including playoffs) and 2-3 against playoff teams on the road.

Meanwhile, the Detroit Lions, who had an NFL-best +222 point differential last season, will face the Green Bay Packers. Lions' star edge rusher, Aidan Hutchinson, is fully recovered from a broken leg, and he will be a key player to watch in this matchup.

In other news, lines for NFL Week 1 games have been out for over a month, and early betting action has already moved the number in every single game. It's recommended to bet on certain games earlier in the week, as more line movement is expected as the weekend approaches.

Reigning MVP Josh Allen is still playing at a high level, but Derrick Henry, who ran for 1,921 yards in his first season with the Ravens, may not repeat that performance due to his age and high carry count.

The game on Thursday will be between the Chiefs and Chargers in Sao Paulo, Brazil. NFL Week 1 starts on Thursday and ends on Monday. The Lions are currently being offered at +3.5 points.

Stay tuned for more updates and analysis as the NFL season gets underway!

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