L-Tryptophan synthesized through fermentation with Escherichia coli strain CCTCC M 2024517
The European Union (EU) has approved a new feed additive containing L-tryptophan, a crucial amino acid essential for animal nutrition. The authorization is sought under Article 4(1) for L-tryptophan produced by fermentation with a specific strain of Escherichia coli (CCTCC M 2024517), and it is intended for all animal species under the category/functional group 3(c) 'nutritional additives'/'amino acids, their salts and analogues'.
The feed additive contains L-tryptophan with a minimum purity of 98% (w/w based on dry matter). For the identification of the feed additive, the European Reference Laboratory (EURL) recommends the "L-tryptophan" monograph of the Food Chemical Codex (FCC).
The method used for determining tryptophan in the feed additive, premixtures, compound feed, and water is based on high performance liquid chromatography (HPLC) with fluorescence detection (FLD), as described in Commission Regulation (EC) No 152/2009. This method is also available as a ring-trial validated method EN ISO 13904 for the determination of free tryptophan in commercial products and premixtures (containing more than 2% (w/w) of tryptophan) and for the determination of free and total tryptophan in compound feed.
The method in Commission Regulation (EC) No 152/2009 is applicable for the determination of both free (synthetic and natural) and total (peptide-bound and free) tryptophan in feed. Notably, the method does not distinguish between the amino acid enantiomers.
For official control, the EURL recommends the use of the above-mentioned two ring-trial validated methods based on HPLC-FLD to determine tryptophan in the feed additive, premixtures, compound feed, and water. This ensures accurate and consistent measurement of the feed additive's L-tryptophan content.
The applicant for the authorization of this L-tryptophan feed additive is CJ Europe GmbH. The feed additive is intended to be added directly to compound feed or through complementary feed, premixtures, and water.
This new feed additive is expected to contribute significantly to animal nutrition, particularly in maintaining optimal tryptophan levels in feed, which is crucial for various physiological processes in animals.
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