Week 1 NFL predictions, probabilities, top wagers suggested by a reliable model: A five-team football parlay stands a chance to yield 25-fold returns

The NFL regular season kicks off with a host of exciting matchups, and here's a look at some of the most anticipated games and their respective odds.

In a much-anticipated rematch, the Cincinnati Bengals will face off against their division rivals, the Cleveland Browns, in their first regular-season game of 2025. The Bengals ended their 2024 season on a high note, winning their final five games, but were unable to secure a playoff spot despite a near-MVP year by quarterback Joe Burrow. Burrow, who has a record of 3-5 against the Browns, will be looking to turn the tide in this rivalry. The Bengals are currently 5.5-point favorites in this matchup.

Elsewhere, the Washington Commanders are favored (-6) in their Week 1 match against the New York Giants. Commanders' quarterback Jayden Daniels had a dominant 2024 season, completing 69% of his passes for 3,568 yards, 25 touchdowns with just nine interceptions. Terry McLaurin, the Commanders' top receiver, has a new deal and is expected to be in the lineup for the opener. The Commanders won both meetings against the Giants last season, and the over/under for total points scored in this game is set at 45.5.

Another intriguing matchup sees Aaron Rodgers facing his former team, as the Pittsburgh Steelers travel to take on the New York Jets. The latest Week 1 NFL odds have the Steelers as 3-point favorites on the road. The over/under for total points scored in this game is 38.5, the lowest total of the week.

A computer model, which simulates every NFL game 10,000 times, has locked in five confident NFL best bets for Week 1. If successfully parlayed, these picks would result in a payout of nearly 25-1. The model's Week 1 NFL picks can be found on a specific website, and new users can also benefit from a DraftKings promo code offering $300 in bonus bets instantly and over $200 off NFL Sunday Ticket.

The model predicts the Commanders to cover in over 60% of simulations in their Week 1 match against the Giants. It has also identified four other NFL matchups where it believes the line is way off. Visiting the website can provide information on the model’s top Week 1 NFL picks and NFL parlay opportunities.

As the NFL season gets underway, these matchups promise to provide plenty of excitement and drama. Stay tuned for more updates and analysis as the action unfolds.

Week 1 NFL predictions, probabilities, top wagers suggested by a reliable model: A five-team football parlay stands a chance to yield 25-fold returns