Weight loss medications may potentially lead to an increase in hair loss, according to recent research findings.

In a recent study, researchers from the University of British Columbia have found that those taking the weight loss drug semaglutide are more likely to experience hair loss compared to those taking bupropion-naltrexone. The study, which was the first to examine this association in a real-life clinical setting, specifically for those taking semaglutide purely for weight loss, has raised concerns for potential users.

The researchers analysed data from the IQVIA PharMetrics Plus for Academics database, which included information on 16 million people. The study included nearly 2,000 people taking semaglutide, with none of the participants having been diagnosed with diabetes or having a history of taking similar drugs. For the purposes of this study, all participants selected were first-time semaglutide users.

The study found that women taking semaglutide were more likely to experience hair loss than men. Rapid weight loss, associated with semaglutide, may increase the risk of hair loss due to physiological stress. Additionally, semaglutide may lead to insufficient intake of vitamins and nutrients necessary for healthy hair growth due to appetite suppression. Users of semaglutide may also experience gastrointestinal issues, which could impact healthy hair growth by hindering nutrient retention.

It's possible that semaglutide causes hormone dysregulation, which can also impact hair growth. The active ingredient in both Wegovy and Ozempic, semaglutide, was associated with an increased risk of hair loss according to the study. The Food and Drug Administration (FDA) has reported more hair loss events with GLP-1 agonists, the class of drugs to which semaglutide belongs, compared to other antihyperglycemics.

The researchers encourage consumers to consider these side effects before beginning semaglutide treatment, particularly those using it for recreational weight loss. The risk-benefit analysis for using semaglutide may differ for those with diabetes or morbid obesity compared to those using it for recreational weight loss.

Women who may want to use semaglutide should be aware of the increased risk of hair loss as a potential limitation of the drug. It is important for potential users to weigh the benefits of rapid weight loss against the potential risks to their hair health. The search results do not specify which research institution conducted the study on the impact of weight loss drugs on hair loss.