Zilbrysq for Myasthenia Gravis: Dosage Details, Potential Side Effects, Pricing Information, and Further Details
Zilbrysq, a new medication for the treatment of generalized myasthenia gravis (gMG), was introduced in the German market in 2024. This injectable solution is a complement inhibitor, thought to work by reducing the immune response.
Zilbrysq is prescribed for adults who have antibodies against the acetylcholine receptor. A blood test is required to check for anti-AchR antibodies before starting the treatment. The medication comes in solution form in single-use prefilled syringes and is given by subcutaneous injection once daily.
The recommended dosage is based on body weight. Symptoms of gMG, such as blurry or double vision, difficulty chewing, swallowing, and speaking, drooping eyelids, weakened muscles in eyes, neck, arms, and legs, and fatigue, may improve with the use of Zilbrysq.
However, Zilbrysq has a boxed warning due to the risk of serious meningococcal infections. The Zilbrysq REMS program requires doctors to enroll and vaccinate patients with the meningococcal vaccine at least 2 weeks before starting Zilbrysq.
It's not known whether Zilbrysq should be used during pregnancy or while breastfeeding. If you're planning a pregnancy or can become pregnant, talk with your doctor before using this medication. If you're sexually active and you or your partner can become pregnant, talk with your doctor about your birth control options while using Zilbrysq.
Zilbrysq contains the active ingredient zilucoplan. Other drugs similar to Zilbrysq include eculizumab (Soliris) and ravulizumab-cwvz (Ultomiris).
The cost of Zilbrysq can vary depending on insurance, location, and pharmacy. For financial support or help understanding your insurance coverage for Zilbrysq, contact the ONWARD program at 844-669-2731 or visit the program website.
It's important to note that Zilbrysq is not known to interact with other medications, herbs, supplements, foods, or alcohol. However, share information about all drugs, vitamins, herbs, and supplements you take with your doctor and pharmacist to avoid potential interactions.
For more information about Zilbrysq's mechanism of action, talk with your doctor or pharmacist. For information on the effectiveness of Zilbrysq for gMG, talk with your doctor or view the drug's prescribing information.
Zilbrysq has a boxed warning, the most serious warning from the FDA. For this reason, it's crucial to discuss your health history with your doctor, especially if you have pancreatitis, certain infections, a previous allergic reaction to this or a similar drug, are pregnant, or breastfeeding.
As with any medication, the benefits and risks should be carefully considered. If you experience any severe side effects while using Zilbrysq, seek immediate medical attention. Difficulty breathing, which may cause shortness of breath, could be a sign of a serious side effect.
In conclusion, Zilbrysq is a new treatment option for adults with generalized myasthenia gravis who have antibodies against the acetylcholine receptor. While it offers potential benefits, it's essential to understand the risks and discuss your health history with your doctor before starting treatment.
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